The following articles (labelled with PubMed ID or TBD) are for your review| PMID | Article Title | Published | Deposition |
|---|
| 36889150 |
Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site. |
15-MAR-2023 |
23-APR-2024 |
| 33647840 |
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer. |
01-APR-2021 |
26-MAR-2022 |
| 33310545 |
The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity. |
01-JAN-2021 |
24-MAR-2022 |
| 32503687 |
Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier. |
15-JUN-2020 |
13-AUG-2021 |
| 27458733 |
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. |
08-SEP-2016 |
28-FEB-2021 |
| 27213719 |
Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells. |
23-JUN-2016 |
28-FEB-2021 |
| 31679978 |
Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor ? and inhibition of de novo purine nucleotide biosynthesis. |
01-DEC-2019 |
25-FEB-2021 |
| 31176699 |
Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection. |
01-AUG-2019 |
24-FEB-2021 |
| 29701475 |
Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. |
10-MAY-2018 |
18-FEB-2021 |
| 23895532 |
Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents. |
12-SEP-2013 |
01-SEP-2020 |
| 30266542 |
Clickable photoaffinity ligands for the human serotonin transporter based on the selective serotonin reuptake inhibitor (S)-citalopram. |
15-NOV-2018 |
18-AUG-2020 |
| 30098869 |
Design, synthesis and preclinical evaluation of 5-methyl-N |
01-OCT-2018 |
17-AUG-2020 |
| 29691153 |
Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents. |
15-MAY-2018 |
17-AUG-2020 |
| 29425443 |
Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. |
08-MAR-2018 |
16-AUG-2020 |
| 29144746 |
Oxyprenylated Phenylpropanoids Bind to MT1 Melatonin Receptors and Inhibit Breast Cancer Cell Proliferation and Migration. |
22-DEC-2017 |
10-JUL-2020 |
| 28258797 |
Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. |
01-APR-2017 |
07-JUL-2019 |
| 27894589 |
Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents. |
15-JAN-2017 |
23-MAY-2019 |
| 26317331 |
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptora and the Proton-Coupled Folate Transporter in Human Tumors. |
10-SEP-2015 |
13-DEC-2016 |
| 27439469 |
Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase. |
16-AUG-2016 |
16-SEP-2016 |
| 25602637 |
Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents. |
12-FEB-2015 |
21-APR-2016 |
| 25882519 |
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents. |
27-APR-2015 |
14-APR-2016 |
| 25234128 |
Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptorsa andß and the proton-coupled folate transporter. |
09-OCT-2014 |
08-MAR-2016 |
| 24890652 |
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents. |
16-JUN-2014 |
12-FEB-2015 |
| 24900865 |
Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential. |
06-JUN-2014 |
11-FEB-2015 |
| 24470841 |
Discovery of potent and selective inhibitors of |
04-OCT-2013 |
25-JUL-2014 |
| 24111942 |
Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor a and inhibition of de novo purine nucleotide biosynthesis. |
14-NOV-2013 |
25-JUL-2014 |
| 23627352 |
Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles. |
13-JUN-2013 |
13-APR-2014 |
| 23332369 |
Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells. |
04-FEB-2013 |
13-APR-2014 |
| 23375090 |
N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents. |
15-FEB-2013 |
24-SEP-2013 |
| 23434139 |
Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents. |
18-MAR-2013 |
24-SEP-2013 |
| 22243528 |
Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier. |
23-FEB-2012 |
17-MAY-2013 |
| 22739090 |
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents. |
03-JUL-2012 |
08-FEB-2013 |
| 20558072 |
Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents. |
13-JUL-2010 |
02-JAN-2013 |
| 20092323 |
Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. |
19-FEB-2010 |
29-DEC-2012 |
| 20056546 |
2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors. |
03-FEB-2010 |
28-DEC-2012 |
| 20085328 |
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry. |
04-FEB-2010 |
27-DEC-2012 |
| 18771252 |
N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase. |
03-OCT-2008 |
19-DEC-2012 |
| 18800768 |
Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine antifolates. |
19-SEP-2008 |
19-DEC-2012 |
| 18605720 |
The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents. |
07-AUG-2008 |
17-DEC-2012 |
| 15615522 |
Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents. |
23-DEC-2004 |
10-DEC-2012 |
| 15615538 |
Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. |
23-DEC-2004 |
10-DEC-2012 |
| 16078850 |
Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. |
04-AUG-2005 |
03-DEC-2012 |
| 15837298 |
Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase. |
19-APR-2005 |
02-DEC-2012 |
| 12570380 |
Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents. |
06-FEB-2003 |
30-NOV-2012 |
| 12408727 |
Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates. |
31-OCT-2002 |
26-NOV-2012 |
| 11384244 |
Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines. |
31-MAY-2001 |
25-NOV-2012 |
| 11052789 |
Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent. |
07-NOV-2000 |
24-NOV-2012 |
| 10956221 |
Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines. |
08-SEP-2000 |
15-NOV-2012 |
| 8917644 |
2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase. |
26-DEC-1996 |
02-NOV-2012 |
| 22370340 |
N¿?¿-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation. |
14-MAR-2012 |
23-JUL-2012 |
| 22119468 |
(±)-2-(N-tert-Butylamino)-3'-[(125)I]-iodo-4'-azidopropiophenone: a dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban). |
30-DEC-2011 |
22-JUL-2012 |
| 22204741 |
N¿?¿-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors. |
16-JAN-2012 |
22-JUL-2012 |
| 15879005 |
Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. |
XX-XXX-2005 |
08-JUN-2012 |
| 21879757 |
Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits b-glycinamide ribonucleotide formyltransferase. |
20-OCT-2011 |
24-MAR-2012 |
| 21550809 |
Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
25-MAY-2011 |
23-MAR-2012 |
| 21144757 |
Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25. |
03-JAN-2011 |
22-AUG-2011 |
| 20804202 |
Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore. |
22-NOV-2010 |
13-JUN-2011 |
| 20403693 |
The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines. |
04-MAY-2010 |
19-NOV-2010 |
| 20403700 |
Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents. |
12-MAY-2010 |
19-NOV-2010 |
| 20117005 |
CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified cross-validated r(2)-guided region selection (q(2)-GRS) routine and its initial application. |
17-FEB-2010 |
01-SEP-2010 |
| 18467105 |
Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents. |
26-MAY-2008 |
11-JAN-2010 |
| 10377234 |
Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase. |
08-JUL-1999 |
10-NOV-2009 |
| 14584957 |
Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents. |
30-OCT-2003 |
10-NOV-2009 |
| 9435890 |
Development of a high-affinity ligand that binds irreversibly to Mel1b melatonin receptors. |
13-FEB-1998 |
10-NOV-2009 |
| 10021916 |
Synthesis and sulfatase inhibitory activities of (E)- and (Z)-4-hydroxytamoxifen sulfamates. |
11-MAY-1999 |
10-NOV-2009 |
| 9046337 |
Synthesis and dihydrofolate reductase inhibitory activities of 2,4-diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolates. |
26-MAR-1997 |
10-NOV-2009 |
| 9191971 |
Synthesis and biological activities of conformationally restricted, tricyclic nonclassical antifolates as inhibitors of dihydrofolate reductases. |
15-JUL-1997 |
10-NOV-2009 |
| 9301665 |
Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii. |
08-OCT-1997 |
10-NOV-2009 |
| 7783147 |
Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases. |
14-JUL-1995 |
10-NOV-2009 |
| 9548816 |
Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines. |
01-MAY-1998 |
10-NOV-2009 |
| 8230134 |
Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents. |
10-DEC-1993 |
10-NOV-2009 |
| 11960504 |
Synthesis of N-[4-[1-ethyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid as an antifolate. |
18-APR-2002 |
10-NOV-2009 |
| 7562910 |
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines. |
25-OCT-1995 |
10-NOV-2009 |
| 15214795 |
Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors. |
24-JUN-2004 |
10-NOV-2009 |
| 1433179 |
5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities. |
18-DEC-1992 |
10-NOV-2009 |
| 9089339 |
Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii. |
01-MAY-1997 |
10-NOV-2009 |
| 8627607 |
Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii. |
25-JUN-1996 |
10-NOV-2009 |
| 10395486 |
Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl] pyrido[2,3-d]pyrimidines. |
22-JUL-1999 |
10-NOV-2009 |
| 9046338 |
Synthesis and biological evaluation of nonclassical 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines with novel side chain substituents as potential inhibitors of dihydrofolate reductases. |
26-MAR-1997 |
10-NOV-2009 |
| 7473577 |
5-Arylthio-substituted 2-amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine antifolates as thymidylate synthase inhibitors and antitumor agents. |
26-DEC-1995 |
10-NOV-2009 |
| 8691474 |
2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases. |
26-AUG-1996 |
10-NOV-2009 |
| 9719595 |
Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents. |
17-SEP-1998 |
10-NOV-2009 |
| 9804692 |
6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents. |
30-NOV-1998 |
10-NOV-2009 |
| 9554874 |
Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases. |
21-MAY-1998 |
10-NOV-2009 |
| 1995884 |
Synthesis and biological activity of 5,11-methylenetetrahydro-5- deazahomofolic acid. |
27-MAR-1991 |
10-NOV-2009 |
| 7658454 |
Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities. |
04-OCT-1995 |
10-NOV-2009 |
| 8164259 |
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. |
24-MAY-1994 |
10-NOV-2009 |
| 15743188 |
CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase. |
03-MAR-2005 |
10-NOV-2009 |
| 7752201 |
6-substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents. |
21-JUN-1995 |
10-NOV-2009 |
| 19748785 |
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. |
15-OCT-2009 |
06-NOV-2009 |
| 19719239 |
Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. |
13-AUG-2009 |
29-SEP-2009 |
| 18072727 |
Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
10-JAN-2008 |
17-MAR-2008 |
| 16279780 |
Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and a |
17-NOV-2005 |
05-NOV-2007 |
| 16451071 |
Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1). |
09-FEB-2006 |
05-NOV-2007 |
| 17552508 |
Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates. |
28-JUN-2007 |
08-OCT-2007 |
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